The youngest daughter of a performing family, vivacious and vulnerable Patricia Arquette rose through the 1990s independent film world to become a leading player for directors like Tim Burton, David Lynch and Sean Penn. Her breakthrough in Tony Scott’s crime spree “True Romance” (1993) led to more risky but stylish fare, including “Lost Highway” (1997) and “Stigmata” (1999), but the actress also proved her widespread appeal with mainstream dramas like Martin Scorsese’s “Bring Out the Dead” (1999) and comedies like “Little Nicky” (2000). In 2004, Arquette made an unlikely leap to series TV with resounding success, with her portrayal of a hectic working mom and gifted psychic in NBC’s “Medium” earning the actress multiple Emmy and Golden Globe nominations.