Mano Negra was a multiracial music band fronted by Manu Chao. The band was founded in 1987 by Manu, his brother Antoine, and his cousin Santiago Casariego in Paris, France. It split up around 1995, but many members had already left by 1992.

Mano Negra mixed a number of styles: rock, flamenco, ska, raï, salsa, reggae and african rhythms. The band, which is still revered on three continents, had been among the pioneers of world music fusion and are a direct influence on countless bands in Europe and South America. The mix of African, Latin and other rhythms is often called mestizo or patchanka (which is the name of one of their albums).